FOXO3 and cancer: AKT is a serine/threonine protein kinase that regulates a major pro-survival signaling network and affects a variety of cellular processes including proliferation, survival, and protein translation,1 which makes AKT a potential therapeutic or preventative target for cancer.2 Overexpression of AKT has been correlated with the development and metastasis of various cancers.3, 4, 5 Activation of AKT disturbs the balance of cell survival and apoptosis by promoting pro-survival transcription factors (CREB and NF-KB) and inhibiting the FOXO3a pro-apoptotic transcription factor.6, 7, 8