The depletion of TUG1 in the developing mouse eye was found to block retinal development.20 In addition, dysregulation of TUG1 could participate in the progression of a variety of tumors.21, 22, 23 Our previous study also found that TUG1 could affect cell proliferation through epigenetically regulating HOXB7 by binding to PRC2 in human non-small cell lung cancer.24 However, the biological functions of TUG1 in the control of GC tumorigenesis have not been well characterized, which prompted us to explore the role of TUG1 in human GC. The gene discussed is HOXB7; the disease is gastric cancer.