To assess whether chronic inflammation could regulate C/EBPβ expression in myoblasts in vivo, cancer cachexia was induced in mice using the Lewis lung carcinoma (LLC) syngenic tumor graft model.46, 47 LLC cells were transplanted into mice, which developed tumors (with a mean mass of 2.43±0.31 g) and cachexia within 4 weeks of grafting. The gene discussed is CEBPB; the disease is cancer.