PAX7 and neoplasm: Examination of the number of Pax7+ cells in uninjured WT and cKO muscle from healthy and LLC-grafted mice revealed that while the population of Pax7+ SCs in both healthy WT and cKO TA muscles were comparable, cachexia expanded the Pax7+ population from 1.7 to 3.5% in WT animals, but not in cKO animals bearing the LLC tumor (Figures 5f and g).