CEBPB and Cachexia: Indeed, an increase in SC apoptosis in a cachexia model with more severe weight loss has been observed.55 Moreover, muscle biopsies from patients suffering of gastrointestinal cancers had increased DNA fragmentation, typical of apoptosis, suggesting that loss of muscle cells contributes to wasting in humans.56 These findings would suggest that anti-inflammatory therapy could release the C/EBPβ-imposed blockade of muscle repair and therefore counteract the loss of muscle protein observed in cachexia.57