Furthermore, new soluble markers including the RANK (Receptor activator of nuclear factor kappa-B)/RANKL (Receptor activator of nuclear factor kappa-B ligand)/OPG (Osteoprotegerin) axis, a member of the TNF superfamily, have emerged as a possible link between osteoporosis and cardiovascular disease. The gene discussed is TNFRSF11B; the disease is osteoporosis.