ITGAM and neoplasm: The inflammatory microenvironment introduced by the tumour cells affects the immune effector functions by means of immunosuppressor cells of the tumour-associated macrophage (TAM) type, immature Grl+ and Mac1+ myeloid cells, T regulator lymphocytes, T reg, CD4+ CD25+, natural killer T, NKT, etc. It is also possible that this occurs through the reduction of the number of dendritic cells, which are essential to initiating and maintaining an antitumour immune response [83].