HCV-infected patients who obtain a sustained virological response (SVR) by IFN monotherapy or pegylated-IFN-alpha (PEG-IFNα) and ribavirin demonstrate significant improvement in liver fibrosis [11, 12] and a decrease in the occurrence of decompensated liver disease and HCC [4–9] compared with untreated or non-SVR patients. Here, IFNA1 is linked to hepatocellular carcinoma.