Recent studies have shown that in human hypertension, which is a common precursor for development of heart failure with preserved ejection fraction (HFpEF), cMyBP-C phosphorylation is reduced and may contribute to a prolongation of XB attachment time at the myofilament level, thereby impairing diastolic relaxation (Donaldson et al., 2012). Here, MYBPC3 is linked to Hypertension.