Measurements from human heart failure samples suggest that cMyBP-C phosphorylation can also contribute to length-dependent acceleration of the rate of XB detachment, as myocardium isolated from patients with hypertrophic cardiomyopathy (HCM) displayed reduced cMyBP-C phosphorylation exhibited impaired LDA (Sequeira et al., 2013). Here, MYBPC3 is linked to hypertrophic cardiomyopathy.