In summary, our data demonstrate that increased VEGF‐A levels, as they can occur in aging tissues due to increased hypoxia or oxidative damage, exacerbate normal age‐associated changes and may lead to the manifestation of progressive pathologies resembling those in human senile cataracts and AMD, suggesting shared pathomechanisms between these distinct age‐related eye diseases. The gene discussed is VEGFA; the disease is Age-related cataract.