The observation of key markers that accumulate in human eyes with AMD also in evolving AMD‐like lesions in eyes of VEGF‐Ahyper mice (e.g. the accumulation of complement C1q and C5b‐9) further supports the clinical significance and pathophysiological relevance of findings in this AMD mouse model for the human disease. The gene discussed is VEGFA; the disease is age-related macular degeneration.