In preliminary experiments with 6‐week‐ to 2‐month‐old VEGF‐Ahyper mice that lacked either Nlrp3, Il1r1, or Il18, we had previously observed the occasional occurrence of some VEGF‐A‐induced chorioretinal pathologies, but we had not performed a detailed analysis of the age‐dependent AMD‐like pathologies in these mice with progressive age (Marneros, 2013). Here, IL1R1 is linked to age-related macular degeneration.