Oxidative stress as well as sublytic complement C5b‐9 attack on cells can result in IL‐1β release through activation of the NLRP3 inflammasome (Laudisi et al, 2013; Triantafilou et al, 2013), and C5b‐9 was shown to be increased in CNV lesions in human eyes with AMD (Johnson et al, 2000; Mullins et al, 2014). This evidence concerns the gene NLRP3 and age-related macular degeneration.