We found that increased lenticular VEGF‐A levels correlated with markers of oxidative stress in lenses of aged VEGF‐Ahyper mice, such as decreased levels of the major antioxidant in the lens, reduced glutathione (already prior to cataract formation), and overexpression of NADPH oxidase gp91phox in lenses of aged VEGF‐Ahyper mice with cataracts (Fig 4D and E). Here, FMO5 is linked to cataract.