In conclusion, NLRP3 inflammasome‐mediated IL‐1β activation promotes VEGF‐A‐induced progressive eye pathologies that resemble aspects of both neovascular AMD (CNV) and non‐exudative AMD (RPE/photoreceptor degeneration and accumulation of sub‐RPE deposits). Here, NLRP3 is linked to age-related macular degeneration.