LIPE and obesity due to melanocortin 4 receptor deficiency: Treatment of human adipocytes with HCA-SX resulted in a significant down-regulation of 348 and induction of 366 fat- and obesity-related genes such as hormone sensitive lipase, peroxisome proliferator-activated receptors gamma (PPARγ), coactivator 1α, Leptin, and hypoxia-inducible factor-1 genes [69].