The role of AQP1 in tumour migration and angiogenesis was first demonstrated in a murine melanoma tumour model: in AQP1 null mice tumours were smaller with fewer micro-vessels and more extensive necrosis as compared to AQP1 wild type mice, suggesting that AQP1 deletion impaired endothelial cell proliferation and angiogenesis [10]. Here, AQP1 is linked to melanoma.