Migration in HCT-116 cells that express low amounts of AQP1 and AQP5 may be enhanced by expression of the calcium activated chloride channel TMEM16A as it has recently been reported that the high metastatic-potential colon cancer cell lines HCT-116 and SW620 express TMEM16A while primary colon cancer cell lines HCT8 and SW480 cells do not. Here, AQP1 is linked to malignant colon neoplasm.