CHEK1 and infection: Some host genes play pivotal roles in combating infection and the intracellular survival of Mtb. Knockdown of Aatk, Adrbk1, Atp1a3 and Dusp14 in mouse macrophages resulted in a significant decrease in the intracellular mycobacterial load, while knockdown of Chek1 and Wee1 led to a marked increase in the mycobacterial level19.