In contrast, H37Ra significantly suppressed Bmf expression, suggesting that Bmf may be a key regulator of Sp110-mediated host immunity against Mtb. Overall, using an avirulent strain of Mtb and the RAW264.7 murine macrophage cell line, our data revealed the transcriptional basis of Sp110-mediated macrophage resistance to TB. The gene discussed is SP110; the disease is tuberculosis.