All these factors, such as CAND1, PSMD12 and MYCBP2 (among the interconnected transcripts) as well as ELAVL1, EIF2B2, CUL2, UBQLN1, NF1, NIPSNAP1, BTRC, ARFGEF2, COPS3, PLAA, CLTA, ANXA7, SEC23A, USP9X, STAM, HSPA13, RAB11A and RTN3 (co-expressed transcripts and PPIs of C9orf72, VCP, UBQLN2 and OPTN; see Table 4 for detailed associations with the spectrum FTD-genes) should be considered for further investigation in the functional environment. The gene discussed is COPS3; the disease is frontotemporal dementia.