Furthermore, pathogenic variants in TARDBP and the fused in sarcoma (FUS) genes seem nearly absent in FTD comparatively to ALS or ALS-FTD cases [13]; however, given that TARDBP and FUS are pathological hallmarks of FTLD subtypes [10], they likely hold functional relevance in the pathogenesis of FTD. Here, TARDBP is linked to frontotemporal dementia.