CTSC and frontotemporal dementia: Finally, recent genome wide association studies (GWAS) revealed association with FTD for the modifying factor transmembrane protein 106B (TMEM106B) [14, 15] and two further loci, one containing the RAB38, member RAS oncogene family (RAB38) and catepsin C (CTSC) genes, and one pointing to the HLA-locus [16].