LDLR and atherosclerosis: In this study we demonstrate for the first time the use of a monoclonal autoantibody combined with NIRF technology to image and quantify the accumulation of oxLDL in atherosclerosis in vivo. The LO1 antibody that we used reacts with LDL adducted with MDA, and was originally isolated from an Ldlr−/− mouse that had not been subjected to active immunization, giving us the confidence that it is likely to target a biologically relevant endogenous entity.