Li et al. [39] reports that GAPDH is physically associated with p300/CREB binding protein associated factor (PCAF), and histone deacetylase 5(HDAC5) for its higher enzymatic activity by acetylation at active site’s lysine 254 residue in HEK 293 T and A549 lung cancer cell line. The gene discussed is KAT2B; the disease is lung cancer.