However, the findings from these studies are not fully applicable to C1-INH-HAE patients, because this disorder requires longer drug therapy (lasting for years, vs. 2–6 months in endometriosis), although with smaller doses (33–200 mg vs. 400–600 mg in endometriosis, or 50–800 mg in ITP) [21]. This evidence concerns the gene SERPING1 and endometriosis.