NFE2L2 and obesity due to melanocortin 4 receptor deficiency: In addition, it is expected to affect obesity-related complications by mimicking of calorie restriction11, 12via activation of key regulators of metabolic health, such as AMP-activated kinase (AMPK), nuclear factor (erythroid-derived)-like 2 (Nrf2), and nicotinamide adenine dinucleotide NAD+-dependent deacetylase (SIRT1)13.