SGCB and Alzheimer disease: The etiology of AD remains elusive, but several characteristic pathological features, such as amyloid-β (Aβ) deposits2, 3, 4, 5, low levels of acetylcholine6, 7, 8, 9, inflammation, oxidative stress10, 11, 12, downregulation of the nitric oxide/soluble guanylyl cyclase (NO/sGC pathway)13, 14, and impaired homeostasis of biometals15, 16, 17, 18, might play significant roles in AD.