In a model adjusting for sex, age, estimated duration of infection, symptomatic infection, HIV co-infection, interferon-lambda rs12979860 genotype, HCV genotype, and assay run, higher ALT levels (adjusted β = 0.20; 95 % CI: 0.07, 0.32; P = 0.002) and HCV RNA >400,000 IU/mL (vs. < 8,500 IU/mL; adjusted β = 0.16; 95 % CI: 0.03, 0.28; P = 0.014) remained independently associated with higher IP-10 levels (Table 3). This evidence concerns the gene GPT and coinfection.