CYP2R1 and cryohydrocytosis: Exploring the association of IL28B rs12979870, CYP2R1 rs10741657, VDR (rs2228570, rs1544410), OASL rs1169279 and ADAR rs1127309 genes polymorphism with response to antiviral treatment were shown in Tables 1 and 2, it was found that the absence of IL28B rs12979870T allele carrier state (chi2 = 51.69- p < 0.001), the prescence of CYP2R1 rs10741657 and VDR rs2228570 A allele carrier states (chi2 = 4.888- p = 0.027, chi2 = 4.138- p = 0.042 respectively), and OASL rs1169279T allele carrier state (chi2 = 6.23- p = 0.013), were significantly predicting SVR in CHC G4 patients.