CHGA and neoplasm: Univariate analysis was performed using patients’ age (55 years old as the cut-off point which corresponds to the median age in our study), gender, tumour site (gastrointestinal-biliary tract versus pancreas), tumour grade according to WHO 2010 classification (Grade 1 tumours versus Grade 2 and Grade 3 tumours), size (2 cm as cut-off point), chromogranin A immunostatining positivity, functional status, and presence of metastasis on presentation, to identify potential prognostic factors for survival and disease progression.