EXOSC8 and infection: The antiviral function of P9 mediated through inhibition of endosomal acidification might be independent of the blocking of M2 ion channel, since P9 could efficiently inhibit the infection of three amantadine-resistance strains of influenza virus, A/Hong Kong/415742/2009 (H1N1), A/Vietnam/1194/2004 (H5N1) and A/Anhui/1/2013 (H7N9) (Fig. 7)26,27,28.