ABCA4 and age-related macular degeneration: Chemokine signalling is implicated in exacerbating the accumulation of macrophages and photoreceptor death in a range of animal models that demonstrate some features in common with AMD, including laser-induced CNV [31], photo-oxidative stress [16, 32, 33], Abca4−/−Rdh8−/− mice [34], and carboxyethylpyrrole (CEP)-immunised mice [35].