While acute exposure to light damage does not induce some of the classical features of AMD (including drusen and CNV), it induces focal and progressive atrophy of the outer retina and models very effectively the accumulation of subretinal macrophages and up-regulation of chemokines Ccl2, Cxcl1, Cxcl10, and Cxcl11 [41]. This evidence concerns the gene CXCL1 and age-related macular degeneration.