Up-regulation of Ccl2, Cxcl1, Cxcl10, and Cxcl11 are present in all forms of AMD [28], and the Ccl2/Ccr2 axis is implicated in the pathogenic accumulation of macrophages to the outer retina in models that feature aspects of either CNV or geographic atrophy, such as light damage [16, 31–35]. This evidence concerns the gene CXCL1 and age-related macular degeneration.