In carcinoma-derived cell lines (HeLa, HepG2, KLE), for example, disruption of K8/18 filament expression sensitizes the cells to cisplatin-induced apoptosis by increasing FAS expression, but also by decreasing the expression of the anti-apoptotic protein, cellular FLICE inhibitory protein (c-FLIP, also known as CFLAR) [33]. This evidence concerns the gene CFLAR and carcinoma.