Alterations of the normal circadian blood pressure rhythm have been shown to be especially evident in micro- and macro albuminuric but are also more common in normoalbuminuric type 1 diabetic patients than in healthy controls, being related to the level of albumin excretion within the normoalbuminuric range and show a correlation with the progression of diabetic nephropathy and the development and progression of diabetic retinopathy [4, 13]. The gene discussed is ALB; the disease is diabetic kidney disease.