TNF and Hypertension: On one hand infiltration and activation of macrophages in adipose tissue leads to chronic inflammation and secretion of inflammatory molecules, such as tumor necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1, and inducible nitric oxide and on the other decreased nitric oxide impairs vascular relaxation leading to vasoconstriction for hypertension [26, 27].