However, regardless of discrepant CXCR3 situation, overexpression of IFN-inducible CXCR3 ligands predicted poor clinic outcomes of ccRCC patients in TCGA and our study, suggesting a final adverse result caused by IFN-inducible CXCR3 ligands/CXCR3 axis in patients with ccRCC. This evidence concerns the gene IFNA1 and nonpapillary renal cell carcinoma.