Moreover, in RCC, pervious studies found the expression of CXCL9, CXCL10 and CXCL11 increased in tumor compared to normal kidney tissues, suggesting the association with TILs and favorable prognosis, and the promotion of tumor specific immunity in systemic high-dose interleukin-2 (IL-2) therapy [11-14]. The gene discussed is IL2; the disease is renal cell carcinoma.