Moreover, in RCC, pervious studies found the expression of CXCL9, CXCL10 and CXCL11 increased in tumor compared to normal kidney tissues, suggesting the association with TILs and favorable prognosis, and the promotion of tumor specific immunity in systemic high-dose interleukin-2 (IL-2) therapy [11-14]. Here, CXCL11 is linked to neoplasm.