STAT3 and neoplasm: Both the different cDDP responses of PDXs and the fact that cDDP-treated regrowing tumors are less responsive to a second cDDP cycle mirror the clinical setting; 2) among the EMT and CSCs-related genes found to be associated to the response to cDDP, STAT3 could be validated in a cohort of ovarian patients; 3) in cDDP-treated regrowing tumors the levels of several genes involved in EMT and stemness were increased; 4) these results were obtained in both high grade serous and endometrioid histotypes suggesting a possible role of EMT and CSCs also in this latter type of tumor.