Of particular interest in identifying the transcripts involved in breast tumor progression, some up-regulated transcripts functioning as tumor suppressors, including RGS4 (regulator of G-protein signaling 4), AMIGO2 (adhesion molecule with Ig-like domain 2) and RBP1 (Retinoic acid binding protein 1) mRNAs, and some down-regulated transcripts important for tumorigenesis, such as IGF-2, PTGS2 (prostaglandin-endoperoxide synthase 2) and GDF15 (growth differentiation factor 15) were selected and listed in Table S4A and Table S4B. The gene discussed is GDF15; the disease is neoplasm.