GDF15 was implicated in multiple cancer types and correlates with lymph node metastases in endometrial cancer [30, 31] and overexpression of IGF-2 or PTGS2 mRNAs in breast tumors associated with greater mortality and increased metastatic potential [32, 33]. The gene discussed is PTGS2; the disease is metastatic malignant neoplasm in the lymph nodes.