Overexpression of miR-410 in glioma cells strongly inhibited cell proliferation and invasion mediated by targeting MET [30], and that miR-410 directly targeted VEGF and inhibited cell proliferation and contributed to apoptosis in osteosarcoma cells [31], and that miR-410 was lowly expressed in gastric cancer and suppressed migration and invasion by targeting MDM2 [32]. This evidence concerns the gene MDM2 and glioma.