In this study, we identified that miR-410 directly targeted the 3′UTR of SLC34A2 and suppressed its expression transcriptionally and post-transcriptionally, and confirmed that miR-410 promoted the proliferation, invasion and migration of NSCLC cells by down-regulating SLC34A2 in vitro and in vivo. Here, SLC34A2 is linked to non-small cell lung carcinoma.