In this study, we demonstrated that SLC34A2 was directly targeted by miR-410 and inhibited by miR-410 transcriptionally and post-transcriptionally, and the biological roles of miR-410 in NSCLC were mediated by down-regulating SLC34A2 in vitro and in vivo, indirectly implying SLC34A2 played as tumor suppressor in NSCLC. Here, SLC34A2 is linked to non-small cell lung carcinoma.