MTAP and lung adenocarcinoma: A transition state analog inhibitor of MTAP, Methylthio-DaDMe-Immucillin-A (MTDIA) was previously described and shown to be effective following a 6 or 12 day treatment at ∼10 and 100 nM MTDIA when 20 uM MTA was added to the media in both lung adenocarcinoma cell lines and head and neck squamous carcinoma cell lines, respectively [31, 32].