Gene expression changes between tumor with and without gene deletions were negative for MAP2K4 (fold change = −2.37, p = 0.0099), PTEN (fold change = −1.71, p = 0.10) and CDH1 (fold change = −1.59, p = 0.22), but close to one for RB1 (fold change = 1.08, p=0.62). The gene discussed is MAP2K4; the disease is neoplasm.