TP53BP1 and Familial prostate cancer: 53BP1 is also recruited to sites of DSBs together with γH2AX in DU145 prostate cancer cells, in a castration-resistant patient-derived organoid line termed CRPC-PCA3 [38] [7, 39, 40, 41], and in a patient-derived CRC line PP8T, from a patient diagnosed with Gleason's score 8 prostate cancer (Figure 3E).