Using 786-O renal carcinoma cells displaying mutated VHL, it was reported that HIF-2α is stabilized and such stabilization was strikingly associated with the resistance of 786-O cells to NK-mediated lysis since targeting HIF-2α, or decreasing its level by the reconstitution of wild type VHL, restored the resistance of 786-O cells to NK-mediated lysis (Figure 5). This evidence concerns the gene EPAS1 and renal carcinoma.