Also, LIN28A overexpression resulted in upregulation of MMP2 and MMP9 (Figure 7C, 7D), while LIN28A knockdown downregulated the expression of MMP2 and MMP9 in PANC1 cells (Figure S3 C, D), indicating that LIN28A might be critical for invasion of pancreatic cancer cells. Here, LIN28A is linked to familial pancreatic carcinoma.