To clarify whether LIN28A expression is associated with stemness maintenance of pancreatic cancer cells, LIN28A or Vector were overexpressed in PaTu8988 and SW1990 cells, we found that LIN28A promoted OCT4, NANOG, LIN28B and c-myc expression (Figure 6A), as well as the sphere formation and colony-forming ability (Figure 6B and Figure S2). The gene discussed is LIN28B; the disease is familial pancreatic carcinoma.