CD226 and type 2 diabetes mellitus: Using sandwich ELISA, we found that soluble CD226 levels in fasting plasma were indistinguishable between T2DM patients (n = 94, range: 0.10-12.57 ng/ml, median: 1.45 ng/ml) and healthy controls (n = 50, range: 0.10-5.05 ng/ml, median: 1.57 ng/ml) (Figure 7A).