This result was corroborated by a reduction of HIF-1α protein in tumor cells with HDCA4 inhibition (Supplementary Figure 4B), as well as co-localization of HDAC4/HIF-1α, HDAC4/14-3-3 and HIF-1α/14-3-3 in SMMC-7721 cells under hypoxic conditions (Supplementary Figure 4C). Here, HIF1A is linked to neoplasm.