Thus, evaluation of both HIF-1α and 14-3-3ζ expression is a powerful predictor of poor prognosis in HCC, leading further support to a model of 14-3-3ζ increasing HIF-1α expression through enhancement of protein stability, resulting in an enhanced EMT followed by metastases of HCC cells and the formation of PVTT (Figure 6C). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.