In addition, RUNX1high patients with CN-AML were more likely to have higher expression of ERG, BAALC, WT1, DNMT3B, TCF4, ITPR2 and MAPKBP1 (P < 0.001, P = 0.028, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively) and low LEF1 (P < 0.001) compared with RUNX1low patients (Supplementary Table 1). The gene discussed is LEF1; the disease is acute myeloid leukemia.