Gene sets related to cell proliferation and cell cycle regulation, particularly c-KIT, FLT3, MYCN, MYB, MYC and CDK6, were up-regulated in the CN-AML patients with RUNX1high, while gene sets related to independent unfavorable prognostic factors, particularly ERG, WT1 and DNMT3B, were also up-regulated, and gene sets related to apoptosis, immune activation of NK cell and independent superior prognostic factor were down-regulated. Here, DNMT3B is linked to acute myeloid leukemia.