ITPR2 and acute myeloid leukemia: We found no link between RUNX1 expression and other gene mutations, but RUNX1high patients with CN-AML were more likely to highly express ERG, WT1, DNMT3B, TCF4, MIR155HG, ITPR2 and MAPKBP1 (P < 0.001, P < 0.001, P < 0.001, P < 0.001, P = 0.01, P < 0.001, and P< 0.001, respectively) (Table 1, Supplementary Figure 1).