Conversely, production of IL-6 has been shown to be necessary and sufficient for NOX2 increase in the ketamine model of schizophrenia [49], as well as the degeneration of forebrain GABAergic interneurons, along with cognitive impairment in aged mice, through activation of the neuronal NADPH oxidase [50]. The gene discussed is FMO5; the disease is Cognitive impairment.