We have previously demonstrated the presence of functional P2X7 receptors in human lung mast cells [25]; given the recent corroborating evidence for the involvement of P2X7 receptors in asthma risk and severity in children, and in another chronic inflammatory condition involving mast cells, namely Crohn’s disease, the results of our study strongly support the potential repositioning of P2X7 selective antagonists for the treatment of chronic inflammatory conditions in which mast cells play a significant role. Here, P2RX7 is linked to Crohn disease.