TNFSF10 and nervous system disorder: Nevertheless, further investigation is required in order to: (1) clarify the local molecular insights into the mechanisms of action of TRAIL; (2) evaluate possible TRAIL-based treatment strategies, taking opportunely into account the different and complex immunological features of the specific neurological disorders; and (3) develop appropriate delivery systems for both systemic and local approaches based on the specific molecular/clinical features of the diseases in question.