High levels of circulating VEGF have been observed in individuals with various vascular diseases (myocardial infarction [1], stroke [2,3], heart failure [4], and atherosclerosis [5]), neurodegenerative conditions (age-related cognitive decline [6] and Alzheimer dementia [7]), immune inflammatory disorders (rheumatoid arthritis [8], inflammatory bowel disease [9], and Behçet’s disease [10]) and cancers (breast [11,12], uterine [13], gastrointestinal [14,15], lung [16] and prostate [17]). The gene discussed is VEGFA; the disease is cancer.