Our group recently reported that Tie2-expressing monocytes (TEMs), a subpopulation of circulating blood monocytes that was previously identified as pro-angiogenic and immunosuppressive [17, 18], are overrepresented at the invasive front in surgical samples of human glioblastoma and murine glioma models after anti-VEGF therapy [12, 15]. This evidence concerns the gene VEGFA and central nervous system cancer.