In fact, a previous report described a role for soluble Tie2 in countering the development of tumor metastasis in murine models of breast cancer and melanoma [44]; however, the use of soluble Tie2 for treating cancer, including gliomas, has not yet addressed the impact of the treatment on the invasive phenotype induced by anti-angiogenesis therapy [27]. The gene discussed is TEK; the disease is melanoma.