Because we showed that anti-angiogenesis therapy increases Ang2 expression and that Ang2 attracts TEMs, a monocytic subpopulation with tumor-remodeling characteristics, to the tumor/normal tissue interface, we then aimed to target the Ang2/Tie2 axis to counter the invasive phenotype observed after the use of anti-angiogenesis therapies. Here, ANGPT2 is linked to neoplasm.