Due to WWOX often exhibits homozygous deletions and translocation breakpoints under multiple cellular stresses induced by extrinsic or intrinsic factors, such as hypoxia, UV, and DNA damage regents, evidence has shown that WWOX that contains a short-chain dehydrogenase/reductase (SDR) domain is involved in steroid metabolism and bone development, while reduced or lost expression of WWOX will lead to development of metabolic disease [38]. Here, WWOX is linked to metabolic disease.