STRAP knockdown stable clones showed lower cell invasion (Figure 3E) when compared with vector control and parental cells with the same treatments with GSK-3β inhibitors and Wnt3a, suggesting that downregulation of STRAP in CRC cell lines inhibits cell migration and invasion, at least in part, directly through inhibiting Wnt/β-catenin signaling. The gene discussed is WNT3A; the disease is colorectal carcinoma.