In order to better establish the levels and patterns of CCK2R staining in human tissues, a broad set of normal tissues (esophagus, liver, lung, pancreas, stomach, spleen and thyroid) and cancerous tissues (gastrointestinal stromal tumor (GIST), hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), pancreatic adenocarcinoma, and thyroid cancer) were analyzed via immunohistochemistry (IHC) using a monoclonal antibody raised against CCK2R. This evidence concerns the gene CCKBR and thyroid cancer.