Several molecular markers have been identified to possess prognostic value for gastric cancer, including MSI, growth factors (e.g. human epidermal growth factor receptor-2 [HER-2], epidermal growth factor receptor [EGFR], vascular endothelial growth factor [VEGF], etc.), cytokines (e.g. interleukin [IL]-11, IL-6), cell cycle mediators (e.g. cyclin E), apoptosis-associated regulators (e.g. Bcl-2, Fas, survivin), microRNAs (e.g. microRNA [miR]-21, microRNA-214, microRNA-433, etc.)[93]. This evidence concerns the gene ERBB2 and gastric cancer.