Also, to establish whether deregulation of specific oncogenes may further classify COO-based DLBCL subtypes, adding meaningful prognostic information, we performed FISH of BCL6, BCL2, IRF4 and MYC and evaluated the expression of MYC, BCL2, BCL6 and pSTAT3 proteins in the same samples. The gene discussed is IRF4; the disease is diffuse large B-cell lymphoma.