Indeed, overexpression of Sema4D (along with Plexin-B1) is correlated with histological tumor type, TNM stage, and metastasis in prostate and colon cancers [44,45] and a worse prognosis in both soft tissue sarcomas [46] and osteosarcoma [47]. The gene discussed is SEMA4D; the disease is malignant colon neoplasm.