ZC3H12A and digestive system neoplasm: Other cancer-associated genes of interest that were profoundly down-regulated by ATB-346 (and less so by naproxen) included: (i) Reg1, which is up-regulated in human colorectal cancer [43] and is a predictor of cancer-associated death [44]; (ii) Cpa1 and Cpb1, which are induced in gastrointestinal tumors [45] (iii) Amy2, which is up-regulated in a number of cancers including colonic neoplasms [46] and (iv) Pnliprp1, which has been identified in non-dissected tumors and micro-dissected invasive tumor cells [47].