We found that JNK3 deficiency in POMC neurons of HFD-fed mice caused no significant changes in feeding behavior, glucose intolerance, blood glucose concentration, hypertrophy of white and brown adipocytes, and hepatic steatosis compared with control Pomc-cre (PomcWT) mice (Figure 5A,C,E). The gene discussed is MAPK10; the disease is Hepatic steatosis.