MAPK10 and Hyperinsulinemia: Consequences of the increased HFD feeding behavior of Mapk10-/- mice include increased hyperinsulinemia and hyperleptinemia (Figure 1G), increased blood lipid concentrations (Figure 1—figure supplement 1C), decreased glucose tolerance (Figure 1H), and increased insulin resistance (Figure 1I) when fed a HFD, but not a CD.