In contrast, JNK3 deficiency in AgRP neurons in HFD-fed mice caused increased feeding, increased glucose intolerance, increased blood glucose concentration, increased hypertrophy of white and brown adipocytes, and increased hepatic steatosis compared with control Agrp-cre (AgrpWT) mice (Figure 5B,D,F). This evidence concerns the gene MAPK10 and Glucose intolerance.