It is noteworthy that ELISA assay (Supplementary Figure S2B and 2C) and FACS analysis (Supplementary Figure S3A and 3B) showed the similar immunomodulatory effects of mAb04-MICA on MDA-MB-435 cells, and the effect intensity was correlated with the binding rate of mAb04-MICA to VEGFR2-expressed cancer cells. The gene discussed is MICA; the disease is cancer.